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KMID : 0370219860300040193
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Yakhak Hoeji
1986 Volume.30 No. 4 p.193 ~ p.197
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Antineoplastic Natural Products and the Analogues(Ⅹ)
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Abstract
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A strongly cytotoxic fraction (Fc-2, ED50=0.0003μg/ml) against L1210 cell was obtained from the root, seed and fruit of Trichosanthes kirilowii. Administration of Fc-2 prolonged the life span of the BDF1 mice bearing L1210 and the ICR mice bearing S-180 by 135% and 130%, respectively. The Fc-2 affected L1210 cells were enlarged in their diameters two or three times in comparison with the untreated ones. When 20mg/kg of Fc-2 was administered, intraperitoneally, all the mice were killed.
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